Centre on Aging and Health > About CAH > CAH Research Clusters > Biological Basis of Age-Related Brain Disorders

Biological Basis of Age-Related Brain Disorders


Researchers in this cluster focus on the pathophysiology associated with brain conditions such as dementia, head injury/concussion and stroke. More specific projects focus on areas such as the consequences of concussions on the aging brain and on pharmacological and stem cell interventions to reduce or reverse damage to the brain.

Cluster Leader

Josef Buttigieg, Ph.D., Associate Professor, Biology, University of Regina

Patrick Neary, Ph.D., Professor, Kinesiology & Health Studies, University of Regina, and Executive Director of the Dr. Paul Scwann Applied Health and Research Centre.

Cluster Members

Cameron Mang, Ph.D., Assistant Professor, Kinesiology & Health Studies

Sample Publications

Hayward, K. S., Neva, J. L., Mang, C. S., et al. (2017). Interhemispheric pathways are important for motor outcome in individuals with chronic and severe upper limb impairment post stroke. Neural Plasticity 2017.


Mang, C. S., Borich, M. R., Brodie, S. M., et al. (2015). Diffusion imaging and transcranial magnetic stimulation assessment of transcallosal pathways in chronic stroke. Clinical Neurophysiology 126(10), 1959-1971.


Mang, C. S., Campbell, K. L., Ross, C. J., and Boyd, L. A. (2013). Promoting neuroplasticity for motor rehabilitation after stroke: Considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor. Physical Therapy 93(12), 1707-1716.


Wadden, K., Peters, S., Borich, M., et al. (2019). White matter biomarkers associated with motor change in individuals with stroke: A continuous theta burst stimulation study. Neural Plasticity 2019.


For more information, contact cluster leader Dr. Josef Buttigieg at Josef.Buttigieg@uregina.ca or Dr. Patrick Neary at Patrick.Neary@uregina.ca